Seasonal malaria vaccination with or without seasonal malaria chemoprevention

Abstract

Seasonally administering RTS,S/AS01E malaria vaccine provided protection against malaria on par with regular doses of chemopreventative drugs. Simultaneously administering both interventions further reduced malaria cases, hospitalizations, and deaths due to malaria. Febrile seizures occurred in five vaccinated children one day after vaccination, but all children recovered and experienced no sequelae. No other severe adverse events were linked to the vaccine. – AI-generated abstract.