Work test for Charity Entrepreneurship: Delaying aging

Abstract

Similarly to how the germ theory of disease led to the discovery and implementation of many simple interventions like washing hands or vaccines, the theory that aging-related diseases are actually aging-caused, might lead to the next big jump in global life expectancy. Accelerating, distributing and incentivizing this research might therefore yield many possible cost-effective programs. [In case you are interested, in the end I didn’t make it into CE, but this work test was not the last round.] \textasciicircumGarmany, A., Yamada, S. & Terzic, A. Longevity leap: mind the healthspan gap. npj Regen Med 6, 57 (2021).\textasciicircumSantesmasses, D., Castro, J.P., Zenin, A.A., Shindyapina, A.V., Gerashchenko, M.V., Zhang, B., Kerepesi, C., Yim, S.H., Fedichev, P.O. and Gladyshev, V.N. COVID-19 is an emergent disease of aging. Aging Cell (2020). \textasciicircumGermany’s population by 2050. Results of the 11th coordinated population projection (2006).\textasciicircumOffice for National Statistics, Health state life expectancies by national deprivation deciles, England: 2017 to 2019 (2021).\textasciicircumScott, A.J., Ellison, M. & Sinclair, D.A. The economic value of targeting aging. Nat Aging 1, 616–623 (2021).\textasciicircumGlobal Burden of Disease (2019)\textasciicircumLongevity investment 2021: from Seed to SPAC (2021).\textasciicircumMandsager K, Harb S, Cremer P, Phelan D, Nissen SE, Jaber W. Association of Cardiorespiratory Fitness With Long-term Mortality Among Adults Undergoing Exercise Treadmill Testing. JAMA Netw Open. (2018).\textasciicircumMamoshina, P., Kochetov, K., Cortese, F. et al. Blood Biochemistry Analysis to Detect Smoking Status and Quantify Accelerated Aging in Smokers. Sci Rep 9, 142 (2019).